We argue that topological deformations and biological functions are dynamically linked in living systems. In the last four decades it has became clear that, although the informational content of the genetic code was embodied in a linear array of bases, it was the three-dimensional spatial structure of the DNA double helix and its capability to change that ultimately would govern its physiological functions. This is very likely a crucial point. As an illustration of this point, in perhaps the most striking biological examples of “form dictates function”, the two complementary parental strands of DNA must separate during semi-conservative replication in order to act as the templates for each of the two newly synthesized daughter strands. This discovery led to recognize that the structure of DNA, while elegant, burdened the cell with previously unimagined topological problems. A huge of theoretical findings and experimental data strongly suggests that the secrets of life and what allows the biological growth of all organisms maybe lies in topology.